Marshall Space Flight Center (MSFC) is one of NASA's premier science Centers. This talk will overview NASA's current science missions, and MSFC proposal prospects and capabilities. Emphasis will be on the X-ray Astrophysics Group's high angular resolution X-ray optics development, and on active and planned missions that use these optics. MSFC is world renown for the development and flight of full-shell X-ray optics. High-value NASA missions, such as the Imaging X-ray Polarimetry Experiment (IXPE) and the Russian-German-led Astronomical Roentgen Telescope – X-ray Concentrator (ART-XC) aboard the Spectrum-Roentgen-Gamma (SRG) observatory, have benefitted from these optics; contributing significantly to our understanding of the Universe. Smaller suborbital (balloon-based and sounding rockets) and ground-based efforts (National Labs) that use MSFC optics are pushing the limits of the state of the art in terms of angular resolution and application. Looking toward future missions, MSFC has an active research program focused on flying a hard X-ray, high-angular resolution (~5 arcsecs) telescope and on achieving sub arcsecond X-ray mirror modules for spaceflight within this decade. Significant science achievements from on-going missions will be presented along with a status on research developments and a look towards future missions.